DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks.

Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability. DNA damage checkpoint factors (DDCF) and DNA damage repair factors (DDRF) play a vital role in maintaining genomic integrity. However, how DDCFs and DDRFs are modulated under physiological and pathological conditions are not fully known. We took an experimental database analysis to determine the expression of 26 DNA D

Design and Implementation of Multi-Channel Readout Circuits for Low-Temperature Environments

Infrared sensors and focal plane imaging arrays are among the most important types of devices in the field of aerospace applications. To effectively amplify the small signals collected by infrared sensors and focal plane imaging arrays for subsequent processing, a new multi-channel preamplifier circuit based on ultra-low temperatures was designed in this study to read the acquisition signals of such devices. The technology of an SMIC 180 nm CMOS with 1.8 V power was adopted to realize the circuit. Meanwhile, an eight-level adjustable gain switch was used to increase the selectivity of signal processing. According to the simulation’s results, the single-channel power consumption of the circuit in the 77 K ultra-low temperature environment was only 5.17 mW. The circuit could drive a large load of 200–400 pF with an open-loop gain of 131.4 dB, which showed excellent performance in driving large loads, providing high gain and consuming less power. Additionally, the circuit exhibited good aspects for front-end signal reading and processing of infrared sensors and focal plane arrays in extreme environments

Spin-Orbit-Torque Switching Mediated by an Antiferromagnetic Insulator

© 2019 American Physical Society. We report the observation of antiferromagnetic insulator-mediated spin-orbit-torque switching in Pt/NiO/Co1-xTbx heterostructures. By measuring the current-induced shift in the magnetic hysteresis loops and the second-harmonic anomalous Hall resistance, we quantitatively determine the spin-orbit-torque efficiency in Pt/NiO/Co1-xTbx samples with different NiO thicknesses, uncovering a systematic evolution of the magnetic switching behavior. The measured spin-orbit-torque efficiency is enhanced in the low NiO thickness regime (1-2 nm), highlighting the efficient spin manipulation across a disordered antiferromagnetic insulator

Accurate Peer-to-Peer Hierarchical Control Method for Hybrid DC Microgrid Clusters

Hybrid DC microgrid clusters contain various types of converters such as BOOST, BUCK, and bidirectional DC/DC converters, making the control strategy complex and difficult to achieve plug-and-play. The common master–slave hierarchical control strategy makes it difficult to achieve accurate and stable system control. This paper proposes an accurate peer-to-peer hierarchical control method for the hybrid DC microgrid cluster, and the working principle of this hierarchical control method is analyzed in detail. The microgrid cluster consists of three sub-microgrids, where sub-microgrid A consists of three BUCK converters, sub-microgrid B consists of three BOOST converters, and sub-microgrid C consists of two bidirectional DC/DC converters. According to all possible operations of various sub-microgrids in the microgrid cluster, the top-, mid-, and bottom-level controls are designed to solve the coordination control problem among different types of sub-microgrids. In this paper, a hybrid microgrid cluster simulation model is built in the PLECS simulation environment, and an experimental hardware platform is designed. The simulation and experiment results verified the accuracy of the proposed control strategy and its fast plug-and-play regulation ability for the system

Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking

Background: Low-intensity ultrasound (LIUS) was shown to be beneficial in mitigating inflammation and facilitating tissue repair in various pathologies. Determination of the molecular mechanisms underlying the anti-inflammatory effects of LIUS allows to optimize this technique as a therapy for the treatment of malignancies and aseptic inflammatory disorders.Methods: We conducted cutting-edge database mining approaches to determine the anti-inflammatory mechanisms exerted by LIUS.Results: Our data revealed following interesting findings: (1) LIUS anti-inflammatory effects are mediated by upregulating anti-inflammatory gene expression; (2) LIUS induces the upregulation of the markers and master regulators of immunosuppressor cells including MDSCs (myeloid-derived suppressor cells), MSCs (mesenchymal stem cells), B1-B cells and Treg (regulatory T cells); (3) LIUS not only can be used as a therapeutic approach to deliver drugs packed in various structures such as nanobeads, nanospheres, polymer microspheres, and lipidosomes, but also can make use of natural membrane vesicles as small as exosomes derived from immunosuppressor cells as a novel mechanism to fulfill its anti-inflammatory effects; (4) LIUS upregulates the expression of extracellular vesicle/exosome biogenesis mediators and docking mediators; (5) Exosome-carried anti-inflammatory cytokines and anti-inflammatory microRNAs inhibit inflammation of target cells via multiple shared and specific pathways, suggesting exosome-mediated anti-inflammatory effect of LIUS feasible; and (6) LIUS-mediated physical effects on tissues may activate specific cellular sensors that activate downstream transcription factors and signaling pathways.Conclusions: Our results have provided novel insights into the mechanisms underlying anti-inflammatory effects of LIUS, and have provided guidance for the development of future novel therapeutic LIUS for cancers, inflammatory disorders, tissue regeneration and tissue repair

Large spin-orbit torque observed in epitaxial SrIrO 3 thin films

© 2019 Author(s). Semimetallic iridate compound SrIrO3 epitaxial films have been deposited by off-axis sputtering, exhibiting excellent crystalline quality as well as smooth surfaces. By performing second-harmonic Hall measurements on a series of SrIrO3/Co1-xTbx bilayers, we quantitatively determined the spin-to-charge interconversion efficiency θ SH of SrIrO3 and discovered a systematic temperature and film thickness dependent evolution behavior. Notably, the measured θ SH reaches a remarkably large number of ∼1.1 at room temperature, which is significantly larger than the value of 5d transition metals and comparable to the values reported in some topological material systems. Our findings are further corroborated by ferromagnetic resonance-driven spin pumping studies in SrIrO3/Py bilayers, highlighting the significant opportunities offered by the iridate compounds in designing next-generation energy-efficient multifunctional spin Hall devices